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Dorota Dudek

Last year PhD student , working in SONATA BIS project. Author of 11 published papers with a total impact factor over 39. Currently working mostly on dissertation.  After work a baking, sport and true crime stories enthusiast.

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Scientific interests:

Bioinorganic and biomedical chemistry, metal ion homeostasis in human pathogens, antimicrobial peptides, zincophores, metallophores, understanding biomolecule – metal interactions, thermodynamics and solution structure of metal-biomolecule complexes.

Used techniques: NMR, UV-Vis, CD, EPR spectroscopy, potentiometry, calorimetry, mass spectrometry, fluoresce

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Education:

 

2016-now - PhD Student, Biological Inorganic Chemistry Research Group, University of Wrocław, Faculty of Chemistry, Wrocław, Poland (head: D.Sc. Elżbieta GumiennaKontecka) Supervisor: Dr. Magdalena Rowińska-Żyrek

2014-2016 - MSc in Chemistry, University of Wrocław, Faculty of Chemistry, Wrocław, Poland Thesis: “Impact of Zn(II) on the fibrillation properties of pramlintide” Supervisor: Dr. Magdalena Rowińska-Żyrek

2013-2015 - MSc in Environmental Biotechnology, Wrocław University of Science and Technology, Faculty of Chemistry Thesis: “Phytotoxicity evaluation of flavonoids fraction extracted from Equisetum arvense L.”

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Scientific experience:

 

Research grants/awards:

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  • W. Iwanowska research project scholarship funded by NAWA, enabling PhD students a stay at a foreign University for the purpose of conducting research.

  • Scholarship in the Max Born Student Scholarship Program in the field of Physical and Chemical Sciences, Wroclaw, Poland, 2019

  • 2019 - SBIC Student Travel Grant for attendance in 19th International Conference on Biological Inorganic Chemistry in Interlaken, Switzeland

  • 2019 -  ISABC15 student travel award, Nara, Japan

  • Fellowships for the PhD students from the University of Wroclaw, 2016-2021

  • Fellowships for the best PhD students from the Rector of University of Wrocław, 2017-2021

  • Pro-quality Fellowship for the best PhD students from the University of Wroclaw, 2017-2021

  • 2017 - grant for the participation to the Third Summer School of Bioinorganic Medicinal Chemistry, corresponding to a discount in the fees for the School. Cagliari, Italy

 

Research projects:

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2018-2019 - Principal investigator in research grant for young scientists entitled “Influence of the membrane mimicking environment on the coordination of Zn2+ and Cu2+ ions by non-aggregating analogues of amylin" funded by the Ministry of Science and Higher Education.

2018-2020 - main executive in Sonata Bis project entitled "The interaction of antimicrobial peptides with metal ions - understanding the relationship between coordination chemistry, structure, thermodynamics and mode of action" funded by National Science Centre. principal investigator: Magdalena Rowińska-Żyrek, DSc, PhD

2016-2018 - main executive in Sonata project entitled „Understanding the interactions of zinc(II) with zincophores and transporters in fungal pathogens” funded by National Science Centre. principal investigator: Magdalena Rowińska-Żyrek, DSc, PhD

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List of papers:

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1. Alghrably Mawadda, Dudek Dorota, Emwas Abdul-Hamid, Jaremko Łukasz, Jaremko Mariusz, Rowińska-Żyrek Magdalena. Copper(II) and amylin analogues: a complicated relationship, Inorganic Chemistry, 2020, 59, 2527-2535

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2. Hecel Aleksandra, Ostrowska Małgorzata, Stokowa-Sołtys Kamila, Wątły Joanna, Dudek Dorota, Miller Adriana, Potocki Sławomir, Matera-Witkiewicz Agnieszka, Domínguez-Martín Alicia, Kozłowski Henryk, Rowińska-Żyrek Magdalena. Zinc(II)—the overlooked éminence grise of chloroquine’s fight against COVID-19? Pharmaceuticals, 2020, 13, 228/1-228/29

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3. Dudek Dorota, Miller Adriana, Draghi Sara, Valensin Daniela, Mikołajczyk Aleksandra, Matera-Witkiewicz Agnieszka, Witkowska Danuta, Stokowa-Sołtys Kamila, Rowińska-Żyrek Magdalena. Zn(II)-alloferon complexes - similar sequence, different coordination modes, no antibacterial activity, Journal of Inorganic Biochemistry, 2020, 213, 111275/1-111275/9

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4. Bellotti Denise, Toniolo Mattia, Dudek Dorota, Mikołajczyk Aleksandra, Guerrini Remo, Matera-Witkiewicz Agnieszka, Remelli Maurizio, Rowińska-Żyrek Magdalena. Bioinorganic chemistry of calcitermin – the picklock of its antimicrobial activity, Dalton Transactions, 2019, 48, 13740-13752

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5. Potocki Sławomir, Delgado Paula, Dudek Dorota, Janicka-Kłos Anna, Kozłowski Henryk, Rowińska-Żyrek Magdalena. Pneumococcal HxxHxH triad - Copper(II) interactions - How important is the 'x'?, Inorganica Chimica Acta, 2019, 488, 255-259

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6. Łoboda Dorota, Rowińska-Żyrek Magdalena. Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II), Dalton Transactions, 2018, 47, 2646-2654

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7. Łoboda Dorota, Kozłowski Henryk, Rowińska-Żyrek Magdalena. Antimicrobial peptide–metal ion interactions : a potential way of activity enhancement. New Journal of Chemistry, 2018, 42, 7560-7568

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8. Bellotti Denise, Łoboda Dorota, Rowińska-Żyrek Magdalena, Remelli Maurizio. Investigation on the metal binding sites of a putative Zn(II) transporter in opportunistic yeast species Candida albicans,  New Journal of Chemistry, 2018, 42, 8123-8130

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9. Miller Adriana, Dudek Dorota, Potocki Sławomir, Czapor-Irzabek Hanna, Kozłowski Henryk, Rowińska-Żyrek Magdalena. Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding? Metallomics, 2018, 10, 1631-1637

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10. Łoboda Dorota, Rowińska-Żyrek Magdalena. Zinc binding sites in Pra1, a zincophore from Candida albicans. Dalton Transactions, 2017, 46, 13695-13703

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11. Łoboda Dorota, Rowińska-Żyrek Magdalena. Zn(II) - pramlintide : stability, binding sites and unexpected aggregation, Journal of Inorganic Biochemistry, 2017, 174, 150-155

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