Ada Miller
PhD student, 4th year. My research focuses on the interactions of antimicrobial peptides with Zn(II) and Cu(II) ions and their influence on the peptides' biological activity. So far I have worked mainly with peptides from the clavanin, piscidin, SAAP and PvHCt families. After work, I like to spend time actively, especially doing water sports.
List of papers:
1.Bellotti Denise, Miller Adriana, Rowińska-Żyrek Magdalena, Remelli Maurizio. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter of Candida albicans. Biomolecules, 2022, 12, 121/1-121/16. doi: 10.3390/biom12010121
2. Miller Adriana, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Wieczorek Robert, Rowińska-Żyrek Magdalena
Chemical “butterfly effect” explaining the coordination chemistry and antimicrobial properties of clavanin complexes.
Inorganic Chemistry, 2021, 60, 12730-12734. doi: 10.1021/acs.inorgchem.1c02101
3. Wątły Joanna, Miller Adriana, Kozłowski Henryk, Rowińska-Żyrek Magdalena
Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules.
Journal of Inorganic Biochemistry, 2021, 217, 111386/1-111386/17. doi: 10.1016/j.jinorgbio.2021.111386
4. Miller Adriana, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Wątły Joanna, Wilcox Dean, Witkowska Danuta, Rowińska-Żyrek Magdalena. Zn-enhanced Asp-rich antimicrobial peptides: N-terminal coordination by Zn(II) and Cu(II), which distinguishes Cu(II) binding to different peptides. International Journal of Molecular Sciences, 2021, 22, 6971/1-6971/20. doi: 10.3390/ijms22136971
5. Hecel Aleksandra, Ostrowska MaÅ‚gorzata, Stokowa-SoÅ‚tys Kamila, WÄ…tÅ‚y Joanna, Dudek Dorota, Miller Adriana, Potocki SÅ‚awomir, Matera-Witkiewicz Agnieszka, Domínguez-Martín Alicia, KozÅ‚owski Henryk, RowiÅ„ska-Å»yrek Magdalena. Zinc(II)—the overlooked éminence grise of chloroquine’s fight against COVID-19? Pharmaceuticals, 2020, 13, 228/1-228/29. doi: 10.3390/ph13090228
6. Dudek Dorota, Miller Adriana, Draghi Sara, Valensin Daniela, Mikołajczyk Aleksandra, Matera-Witkiewicz Agnieszka, Witkowska Danuta, Stokowa-Sołtys Kamila, Rowińska-Żyrek Magdalena. Zn(II)-alloferon complexes - similar sequence, different coordination modes, no antibacterial activity. Journal of Inorganic Biochemistry, 2020, 213, 111275/1-111275/9. doi: 10.1016/j.jinorgbio.2020.111275
7. Miller Adriana, Dudek Dorota, Potocki SÅ‚awomir, Czapor-Irzabek Hanna, KozÅ‚owski Henryk, RowiÅ„ska-Å»yrek Magdalena. Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding? Metallomics, 2018, 10, 1631-1637. doi: 10.1039/c8mt00275d
Presentations:
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1. 17th NPCIB Polish Symposium for Students, 12-15.05.2019, JastrzÄ™bia Góra, Poland ('SAAP and clavanin complexes as a potential new antimicrobial agents', oral presentation)
2. 46th ISMEC International Symposium on Metal Complexes, 11-14.06.2019, Debrecen, Hungary ('Investigation of the SAAP and clavanin complexes - potential new antimicrobial agents', poster)
3. 11th PANIC PhoBiA Annual Nanophotonics International Conference, 12-14.10.2020, WrocÅ‚aw, Poland ('Clavanins – metal interactions: understanding the relationship between coordination chemistry, structure, thermodynamics and the antimicrobial activity', poster)