Metal AMP Research Group
Ada Miller
PhD student, 4th year. My research focuses on the interactions of antimicrobial peptides with Zn(II) and Cu(II) ions and their influence on the peptides' biological activity. So far I have worked mainly with peptides from the clavanin, piscidin, SAAP and PvHCt families. After work, I like to spend time actively, especially doing water sports.
List of papers:
1.Bellotti Denise, Miller Adriana, Rowińska-Żyrek Magdalena, Remelli Maurizio. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter of Candida albicans. Biomolecules, 2022, 12, 121/1-121/16. doi: 10.3390/biom12010121
2. Miller Adriana, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Wieczorek Robert, Rowińska-Żyrek Magdalena
Chemical “butterfly effect” explaining the coordination chemistry and antimicrobial properties of clavanin complexes.
Inorganic Chemistry, 2021, 60, 12730-12734. doi: 10.1021/acs.inorgchem.1c02101
3. Wątły Joanna, Miller Adriana, Kozłowski Henryk, Rowińska-Żyrek Magdalena
Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules.
Journal of Inorganic Biochemistry, 2021, 217, 111386/1-111386/17. doi: 10.1016/j.jinorgbio.2021.111386
4. Miller Adriana, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Wątły Joanna, Wilcox Dean, Witkowska Danuta, Rowińska-Żyrek Magdalena. Zn-enhanced Asp-rich antimicrobial peptides: N-terminal coordination by Zn(II) and Cu(II), which distinguishes Cu(II) binding to different peptides. International Journal of Molecular Sciences, 2021, 22, 6971/1-6971/20. doi: 10.3390/ijms22136971
5. Hecel Aleksandra, Ostrowska MaÅ‚gorzata, Stokowa-SoÅ‚tys Kamila, WÄ…tÅ‚y Joanna, Dudek Dorota, Miller Adriana, Potocki SÅ‚awomir, Matera-Witkiewicz Agnieszka, Domínguez-Martín Alicia, KozÅ‚owski Henryk, RowiÅ„ska-Å»yrek Magdalena. Zinc(II)—the overlooked éminence grise of chloroquine’s fight against COVID-19? Pharmaceuticals, 2020, 13, 228/1-228/29. doi: 10.3390/ph13090228
6. Dudek Dorota, Miller Adriana, Draghi Sara, Valensin Daniela, Mikołajczyk Aleksandra, Matera-Witkiewicz Agnieszka, Witkowska Danuta, Stokowa-Sołtys Kamila, Rowińska-Żyrek Magdalena. Zn(II)-alloferon complexes - similar sequence, different coordination modes, no antibacterial activity. Journal of Inorganic Biochemistry, 2020, 213, 111275/1-111275/9. doi: 10.1016/j.jinorgbio.2020.111275
7. Miller Adriana, Dudek Dorota, Potocki SÅ‚awomir, Czapor-Irzabek Hanna, KozÅ‚owski Henryk, RowiÅ„ska-Å»yrek Magdalena. Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding? Metallomics, 2018, 10, 1631-1637. doi: 10.1039/c8mt00275d
Presentations:
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1. 17th NPCIB Polish Symposium for Students, 12-15.05.2019, JastrzÄ™bia Góra, Poland ('SAAP and clavanin complexes as a potential new antimicrobial agents', oral presentation)
2. 46th ISMEC International Symposium on Metal Complexes, 11-14.06.2019, Debrecen, Hungary ('Investigation of the SAAP and clavanin complexes - potential new antimicrobial agents', poster)
3. 11th PANIC PhoBiA Annual Nanophotonics International Conference, 12-14.10.2020, WrocÅ‚aw, Poland ('Clavanins – metal interactions: understanding the relationship between coordination chemistry, structure, thermodynamics and the antimicrobial activity', poster)