Education and Employment

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2025 – awarding of the title of Professor in the field of exact and natural sciences, specialising in chemical sciences

2018  associate professor, Faculty of Chemistry, University of Wroclaw.

2018 – habilitation (DSc), University of Wroclaw, Faculty of Chemistry.

2011 – 2018 - assistant professor, Faculty of Chemistry, University of Wroclaw.

2012 – 2015 - post doctoral researcher, Department of Chemistry, University of Zurich (financed by Marie Curie Intra-European Fellowship (1.10.2013-30.03.2015) and by Sciex (1.06.2012-30.09.2013)).

2011 – PhD in chemistry, University of Wroclaw, Faculty of Chemistry.

2008 –  2011 - PhD student at the Bioinorganic and Biomedical Chemistry Group, Faculty of Chemistry, University of Wroclaw, under the supervision of Prof. Henryk Kozłowski.

2008 M.Sc. Eng. in biotechnology at Wroclaw University of Technology (WUT), Faculty of Chemistry.

2008 M.Sc. in physics at École Normale Supérieure de Cachan, Laboratoire de photonique quantique et moléculaire (LPQM).

60 published papers with a total impact factor of over 240 and four book chapters; Hirsch index 17, cited more than 800 times

Supervisor of 27 master students and (current) supervisor of 5 outstanding PhD students: Klaudia Szarszoń, Anna Ślusarczyk, Gabriela Potoczniak, Jakub Gawłowski and Wojciech Lizak. 

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Research grants/awards:

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1. Ministry of Science Scholarship for Outstanding Young Researchers, 2015-2018.

2. National Science Centre SONATA BIS (PI; amount of funding: 450 000 €), 2018-2023.

3. National Science Centre MAESTRO (main contractor; amount of funding: 880 000 €), 2018-2023.

4. National Science Centre SONATA (PI; amount of funding: 115 000 €) 2015-2018.

5. Marie Curie Intra-European Fellowship FP7-PEOPLE-2012-IEF, 2013-2015.

6. Sciex-NMSch Fellowship, 2012–2013.

7. Award for the best oral presentation at ISABC12, Guangzhou, China, 3-6.12.2013.

8. Polish Foundation of Science Award for Young Scientist 'START' (twice: in 2012 and 2013).

9. Member of the Young Academy of Scholars and Artists, in the scope of which science is disseminated to society.

 

More than 30 presentations at international conferences; 19 of them were oral presentations, including a keynote lecture at 18th International Conference on Biological Inorganic Chemistry (ICBIC18), and 10 invited lectures at renowned international conferences (such as e.g. ICBIC 2019, ISABC 2019, EUROBIC 2018, PPS 2017, MMC-16 2015 or AsBIC7 2014).

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Scientific experience/training:

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1. Post doctoral stay at the Department of Chemistry, University of Zurich .(financed by Marie Curie Intra-European Fellowship (1.10.2013-30.03.2015) and by Sciex (1.06.2012-30.09.2013)).

2. EMBO Paramagnetic NMR summer school, Florence, Italy, 14-19.07.2014.

3. FEBS/EU Practical Training Course 'Chemistry of Metals in Biological Systems', University of Louvain la Neuve, Belgium, 05.2011.

4. Short-term scientific missions, University of Siena, Italy, one to two month stays in 2009, 2010 and 2011, the results showed metal binding sites in the studied peptides.

5. Student internship project in 2 companies: Thermometric AB (TA Instruments, ITC instruments manufacturer) and Inovacia AB (pharmaceutic company); both in Stockholm, Sweden, 07-11.2007, project focused on vaccine adjuvants and their membrane permeability; main technique- calorimetry (ITC).

6. Undergraduate research project in biophysics under the supervision of prof. M. Langner, Wrocław University of Technology, 01.2007- 07.2008, work focused on ITC of biomolecules.

7. Biochemical and biophysical ‘Molecular Nano Biophotonics Summer School’, Porquerolles, France, 06.2007.

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List of papers:

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Dzień Emilia; Mikołajczyk-Tarnawa Aleksandra; Matera-Witkiewicz Agnieszka; Szewczyk Krzysztof; Barceló-Oliver Miquel; Pawlik-Sobecka Lilla; Wątły Joanna; Rowińska-Żyrek Magdalena. “From speciation to action: Cu(II) and Zn(II) tune histatins, but pH and enamel drive efficacy.” Dalton Transactions, 2026, 55, 125–134. DOI: https://doi.org/10.1039/d5dt02485d

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Garstka Kinga; Hecel Aleksandra; Kozłowski Henryk; Domínguez-Martín Alicia; Szewczyk Krzysztof; Rowińska-Żyrek Magdalena. “AdcA lipoprotein involved in Zn(II) transport in Streptococcus mutans – is it as metal-specific as expected?” Dalton Transactions, 2025, 54, 6795–6804. DOI: https://doi.org/10.1039/d5dt00131e

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Dziadas Mariusz; Pachura Natalia; Duda-Madej Anna; Garbicz Mateusz; Gębarowski Tomasz; Domínguez-Martín Alicia; Rowińska-Żyrek Magdalena. “Chloramphenicol glycoside derivative: a way to overcome its antimicrobial resistance and toxicity.” Carbohydrate Research, 2025, 550, 109387/1–109387/7. DOI: https://doi.org/10.1016/j.carres.2025.109387

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Miller Adriana; Matera-Witkiewicz Agnieszka; Mikołajczyk-Tarnawa Aleksandra; Kola Arian; Wiloch Magdalena; Jonsson-Niedziolka Martin; Wieczorek Robert; Wątły Joanna; Valensin Daniela; Rowińska-Żyrek Magdalena. “Cu(II) binding to an antimicrobial shrimp peptide - a small step for structural chemistry, a big leap for medicinal applications.” Chemical Science, 2025, 16, 3447–3458. DOI: https://doi.org/10.1039/d4sc05222f

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Leveraro Silvia; Dzyhovskyi Valentyn; Garstka Kinga; Szebesczyk Agnieszka; Zobi Fabio; Bellotti Denise; Stokowa-Sołtys Kamila; Remelli Maurizio; Rowińska-Żyrek Magdalena. “Metal-Induced Amide Deprotonation and Binding Typical for Cu(II), Not Possible for Zn(II) and Fe(II).” Inorganic Chemistry, 2025, 64, 6751–6760. DOI: https://doi.org/10.1021/acs.inorgchem.5c00672

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Leveraro Silvia; D'Accolti Maria; Marzola Erika; Caselli Elisabetta; Guerrini Remo; Rowińska-Żyrek Magdalena; Remelli Maurizio; Bellotti Denise. “Positively charged residues play a significant role in enhancing the antibacterial activity of calcitermin.” Journal of Inorganic Biochemistry, 2025, 262, 112761/1–112761/14. DOI: https://doi.org/10.1016/j.jinorgbio.2024.112761

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Hecel Aleksandra; Garstka Kinga; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “–HH and –HAAAH motifs act as fishing nets for biologically relevant metal ions in metallopeptides.” Journal of Inorganic Biochemistry, 2024, 252, 112456/1–112456/14. DOI: https://doi.org/10.1016/j.jinorgbio.2023.112456

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Garstka Kinga; Potoczniak Gabriela; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Aspergillus fumigatus ZrfC Zn(II) transporter scavengers zincophore-bound Zn(II).” Dalton Transactions, 2024, 53, 2848–2858. DOI: https://doi.org/10.1039/d3dt04083f

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Szarszoń Klaudia; Mikołajczyk Aleksandra; Grelich-Mucha Manuela; Wieczorek Robert; Matera-Witkiewicz Agnieszka; Olesiak-Bańska Joanna; Rowińska-Żyrek Magdalena; Wątły Joanna. “Bioinorganic chemistry of shepherin II complexes helps to fight Candida albicans?” Journal of Inorganic Biochemistry, 2024, 253, 112476/1–112476/10. DOI: https://doi.org/10.1016/j.jinorgbio.2023.112476

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Kamińska Justyna; Hecel Aleksandra; Słowik Joanna; Rombel-Bryzek Agnieszka; Rowińska-Żyrek Magdalena; Witkowska Danuta. “Characterization of four peptides from milk fermented with kombucha cultures and their metal complexes—in search of new biotherapeutics.” Frontiers in Molecular Biosciences, 2024, 11, 1366588/1–1366588/14. DOI: https://doi.org/10.3389/fmolb.2024.1366588

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Dzień Emilia; Wątły Joanna; Kola Arian; Mikołajczyk Aleksandra; Miller Adriana; Matera-Witkiewicz Agnieszka; Valensin Daniela; Rowińska-Żyrek Magdalena. “Impact of metal coordination and pH on the antimicrobial activity of histatin 5 and the products of its hydrolysis.” Dalton Transactions, 2024, 53, 7561–7570. DOI: https://doi.org/10.1039/d4dt00565a

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Leveraro Silvia; Garstka Kinga; Śliwka Paulina; Janek Tomasz; Rowińska-Żyrek Magdalena; Remelli Maurizio; Bellotti Denise. “Metal coordination governs the antimicrobial efficacy of calcitermin derivatives.” Dalton Transactions, 2024, 53, 12676–12687. DOI: https://doi.org/10.1039/d4dt01514b

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Miller Adriana; Mikołajczyk Aleksandra; Bellotti Denise; Garstka Kinga; Wątły Joanna; Hecel Aleksandra; Wieczorek Robert; Matera-Witkiewicz Agnieszka; Rowińska-Żyrek Magdalena. “Zn(II) and Cu(II) Coordination Enhances the Antimicrobial Activity of Piscidin 3, but Not That of Piscidins 1 and 2.” Inorganic Chemistry, 2024, 63, 12958–12968. DOI: https://doi.org/10.1021/acs.inorgchem.4c01659

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Dzień Emilia; Wątły Joanna; Hecel Aleksandra; Mikołajczyk Aleksandra; Matera-Witkiewicz Agnieszka; Adrover Miquel; Barceló-Oliver Miquel; Domínguez-Martín Alicia; Rowińska-Żyrek Magdalena. “Zn(II) coordination influences the secondary structure, but not antimicrobial activity of the N-terminal histatin 3 hydrolysis product.” Dalton Transactions, 2024, 53, 19202–19213. DOI: https://doi.org/10.1039/D4DT02274B

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Garstka Kinga; Dzyhovskyi Valentyn; Wątły Joanna; Stokowa-Sołtys Kamila; Świątek-Kozłowska Jolanta; Kozłowski Henryk; Barceló-Oliver Miquel; Bellotti Denise; Rowińska-Żyrek Magdalena. “CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores.” Molecules, 2023, 28, 3985/1–3985/14. DOI: https://doi.org/10.3390/molecules28103985

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D'Accolti Maria; Bellotti Denise; Dzień Emilia; Leonetti Carlotta; Leveraro Silvia; Albanese Valentina; Marzola Erika; Guerrini Remo; Caselli Elisabetta; Rowińska-Żyrek Magdalena; Remelli Maurizio. “Impact of C- and N-terminal protection on the stability, metal chelation and antimicrobial properties of calcitermin.” Scientific Reports, 2023, 13, 18228/1–18228/13. DOI: https://doi.org/10.1038/s41598-023-45437-0

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Garstka Kinga; Bellotti Denise; Wątły Joanna; Kozłowski Henryk; Remelli Maurizio; Rowińska-Żyrek Magdalena. “Metal coordination to solute binding proteins – exciting chemistry with potential biological meaning.” Dalton Transactions, 2023, 52, 16140–16150. DOI: https://doi.org/10.1039/d3dt02417b

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Dudek Dorota; Miller Adriana; Hecel Aleksandra; Kola Arian; Valensin Daniela; Mikołajczyk Aleksandra; Barceló-Oliver Miquel; Matera-Witkiewicz Agnieszka; Rowińska-Żyrek Magdalena. “Semenogelins Armed in Zn(II) and Cu(II): May Bioinorganic Chemistry Help Nature to Cope with Enterococcus faecalis?” Inorganic Chemistry, 2023, 62, 14103–14115. DOI: https://doi.org/10.1021/acs.inorgchem.3c02390

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Sykuła Anna; Nowak Adriana; Garribba Eugenio; Dzeikala Aliaksandr; Rowińska-Żyrek Magdalena; Czerwińska Justyna; Maniukiewicz Waldemar; Łodyga-Chruścińska Elżbieta. “Spectroscopic Characterization and Biological Activity of Hesperetin Schiff Bases and Their Cu(II) Complexes.” International Journal of Molecular Sciences, 2023, 24, 761/1–761/21. DOI: https://doi.org/10.3390/ijms24010761

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Wątły Joanna; Szarszoń Klaudia; Mikołajczyk Aleksandra; Grelich-Mucha Manuela; Matera-Witkiewicz Agnieszka; Olesiak-Bańska Joanna; Rowińska-Żyrek Magdalena. “Zn(II) Induces Fibril Formation and Antifungal Activity in Shepherin I, An Antimicrobial Peptide from Capsella bursa-pastoris.” Inorganic Chemistry, 2023, 62, 19786–19794. DOI: https://doi.org/10.1021/acs.inorgchem.3c03409

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Wątły Joanna; Hecel Aleksandra; Wieczorek Robert; Rowińska-Żyrek Magdalena; Kozłowski Henryk. “Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides.” Inorganic Chemistry, 2022, 61, 14247–14251. DOI: https://doi.org/10.1021/acs.inorgchem.2c02584

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Garstka Kinga; Hecel Aleksandra; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Specific Zn(II)-binding site in the C-terminus of Aspf2, a zincophore from Aspergillus fumigatus.” Metallomics, 2022, 14, mfac042/1–mfac042/10. DOI: https://doi.org/10.1093/mtomcs/mfac042

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Dzień Emilia; Dudek Dorota; Witkowska Danuta; Rowińska-Żyrek Magdalena. “Thermodynamic surprises of Cu(II)-amylin analogue complexes in membrane mimicking solutions.” Scientific Reports, 2022, 12, 425/1–425/9. DOI: https://doi.org/10.1038/s41598-021-04197-5

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Dudek Dorota; Dzień Emilia; Wątły Joanna; Matera-Witkiewicz Agnieszka; Mikołajczyk Aleksandra; Hajda Agata; Olesiak-Bańska Joanna; Rowińska-Żyrek Magdalena. “Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity.” Scientific Reports, 2022, 12, 20543/1–20543/8. DOI: https://doi.org/10.1038/s41598-022-24968-y

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Bellotti Denise; Miller Adriana; Rowińska-Żyrek Magdalena; Remelli Maurizio. “Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter of Candida albicans.” Biomolecules, 2022, 12, 121/1–121/16. DOI: https://doi.org/10.3390/biom12010121

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Witkowska Danuta; Szebesczyk Agnieszka; Wątły Joanna; Braczkowski Michał; Rowińska-Żyrek Magdalena. “A comparative study on nickel binding to Hpn-like polypeptides from two Helicobacter pylori strains.” International Journal of Molecular Sciences, 2021, 22, 13210/1–13210/15. DOI: https://doi.org/10.3390/ijms222413210

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Miller Adriana; Matera-Witkiewicz Agnieszka; Mikołajczyk Aleksandra; Wieczorek Robert; Rowińska-Żyrek Magdalena. “Chemical ‘butterfly effect’ explaining the coordination chemistry and antimicrobial properties of clavanin complexes.” Inorganic Chemistry, 2021, 60, 12730–12734. DOI: https://doi.org/10.1021/acs.inorgchem.1c02101

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Bellotti Denise; Rowińska-Żyrek Magdalena; Remelli Maurizio. “How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores.” Current Medicinal Chemistry, 2021, 28, 7312–7338. DOI: https://doi.org/10.2174/1389200222666210514012945

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Hecel Aleksandra; Kola Arian; Valensin Daniela; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Metal specificity of the Ni(II) and Zn(II) binding sites of the N-terminal and G-domain of E. coli HypB.” Dalton Transactions, 2021, 50, 12635–12647. DOI: https://doi.org/10.1039/d1dt02126e

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Wątły Joanna; Miller Adriana; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules.” Journal of Inorganic Biochemistry, 2021, 217, 111386/1–111386/17. DOI: https://doi.org/10.1016/j.jinorgbio.2021.111386

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Bellotti Denise; Sinigaglia Angelica; Guerrini Remo; Marzola Erika; Rowińska-Żyrek Magdalena; Remelli Maurizio. “The N-terminal domain of Helicobacter pylori's Hpn protein: The role of multiple histidine residues.” Journal of Inorganic Biochemistry, 2021, 214, 111304/1–111304/12. DOI: https://doi.org/10.1016/j.jinorgbio.2020.111304

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Miller Adriana; Matera-Witkiewicz Agnieszka; Mikołajczyk Aleksandra; Wątły Joanna; Wilcox Dean; Witkowska Danuta; Rowińska-Żyrek Magdalena. “Zn-enhanced Asp-rich antimicrobial peptides: N-terminal coordination by Zn(II) and Cu(II), which distinguishes Cu(II) binding to different peptides.” International Journal of Molecular Sciences, 2021, 22, 6971/1–6971/20. DOI: https://doi.org/10.3390/ijms22136971

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Alghrably Mawadda; Dudek Dorota; Emwas Abdul-Hamid; Jaremko Łukasz; Jaremko Mariusz; Rowińska-Żyrek Magdalena. “Copper(II) and amylin analogues: a complicated relationship.” Inorganic Chemistry, 2020, 59, 2527–2535. DOI: https://doi.org/10.1021/acs.inorgchem.9b03498

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Hecel Aleksandra; Kola Arian; Valensin Daniela; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Metal complexes of two specific regions of ZnuA, a periplasmic zinc(II) transporter from Escherichia coli.” Inorganic Chemistry, 2020, 59, 1947–1958. DOI: https://doi.org/10.1021/acs.inorgchem.9b03298

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Bellotti Denise; Rowińska-Żyrek Magdalena; Remelli Maurizio. “Novel insights into the metal binding ability of ZinT periplasmic protein from Escherichia coli and Salmonella enterica.” Dalton Transactions, 2020, 49, 9393–9403. DOI: https://doi.org/10.1039/d0dt01626h

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Ben-Shushan Shira; Hecel Aleksandra; Rowińska-Żyrek Magdalena; Kozłowski Henryk; Miller Yifat. “Zinc binding sites conserved in short neuropeptides containing a diphenylalanine motif.” Inorganic Chemistry, 2020, 59, 925–929. DOI: https://doi.org/10.1021/acs.inorgchem.9b03199

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Hecel Aleksandra; Ostrowska Małgorzata; Stokowa-Sołtys Kamila; Wątły Joanna; Dudek Dorota; Miller Adriana; Potocki Sławomir; Matera-Witkiewicz Agnieszka; Domínguez-Martín Alicia; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Zinc(II)—the overlooked éminence grise of chloroquine’s fight against COVID-19?” Pharmaceuticals, 2020, 13, 228/1–228/29. DOI: https://doi.org/10.3390/ph13090228

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Dudek Dorota; Miller Adriana; Draghi Sara; Valensin Daniela; Mikołajczyk Aleksandra; Matera-Witkiewicz Agnieszka; Witkowska Danuta; Stokowa-Sołtys Kamila; Rowińska-Żyrek Magdalena. “Zn(II)-alloferon complexes - similar sequence, different coordination modes, no antibacterial activity.” Journal of Inorganic Biochemistry, 2020, 213, 111275/1–111275/9. DOI: https://doi.org/10.1016/j.jinorgbio.2020.111275

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Hecel Aleksandra; Kołkowska Paulina; Krzywoszyńska Karolina; Szebesczyk Agnieszka; Rowińska-Żyrek Magdalena; Kozłowski Henryk. “Ag+ complexes as potential therapeutic agents in medicine and pharmacy.” Current Medicinal Chemistry, 2019, 26, 624–647. DOI: https://doi.org/10.2174/0929867324666170920125943

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Bellotti Denise; Toniolo Mattia; Dudek Dorota; Mikołajczyk Aleksandra; Guerrini Remo; Matera-Witkiewicz Agnieszka; Remelli Maurizio; Rowińska-Żyrek Magdalena. “Bioinorganic chemistry of calcitermin – the picklock of its antimicrobial activity.” Dalton Transactions, 2019, 48, 13740–13752. DOI: https://doi.org/10.1039/c9dt02869b

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Witkowska Danuta; Rowińska-Żyrek Magdalena. “Biophysical approaches for the study of metal-protein interactions.” Journal of Inorganic Biochemistry, 2019, 199, 110783/1–110783/10. DOI: https://doi.org/10.1016/j.jinorgbio.2019.110783

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Rowińska-Żyrek Magdalena; Więch Anna; Wątły Joanna; Wieczorek Robert; Witkowska Danuta; Ożyhar Andrzej; Orłowski Marek. “Copper(II)-binding induces a unique polyproline type II helical structure within the ion-binding segment in the intrinsically disordered F-domain of ecdysteroid receptor from Aedes aegypti.” Inorganic Chemistry, 2019, 58, 11782–11792. DOI: https://doi.org/10.1021/acs.inorgchem.9b01826

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Hecel Aleksandra; Rowińska-Żyrek Magdalena; Kozłowski Henryk. “Copper(II)-induced restructuring of ZnuD, a Zinc(II) transporter from Neisseria meningitidis.” Inorganic Chemistry, 2019, 58, 5932–5942. DOI: https://doi.org/10.1021/acs.inorgchem.9b00265

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Potocki Sławomir; Delgado Paula; Dudek Dorota; Janicka-Kłos Anna; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Pneumococcal HxxHxH triad - Copper(II) interactions - How important is the 'x'?” Inorganica Chimica Acta, 2019, 488, 255–259. DOI: https://doi.org/10.1016/j.ica.2019.01.029

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Więch Anna; Rowińska-Żyrek Magdalena; Wątły Joanna; Czarnota Aleksandra; Hołubowicz Rafał; Szewczuk Zbigniew; Ożyhar Andrzej; Orłowski Marek. “The intrinsically disordered C-terminal F domain of the ecdysteroid receptor from Aedes aegypti exhibits metal ion-binding ability.” Journal of Steroid Biochemistry and Molecular Biology, 2019, 186, 42–55. DOI: https://doi.org/10.1016/j.jsbmb.2018.09.008

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Bellotti Denise; Tocchio Cinzia; Guerrini Remo; Rowińska-Żyrek Magdalena; Remelli Maurizio. “Thermodynamic and spectroscopic study of Cu(II) and Zn(II) complexes with the (148–156) peptide fragment of C4YJH2, a putative metal transporter of Candida albicans.” Metallomics, 2019, 11, 1988–1998. DOI: https://doi.org/10.1039/c9mt00251k

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Wątły Joanna; Hecel Aleksandra; Wieczorek Robert; Świątek-Kozłowska Jolanta; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Uncapping the N-terminus of a ubiquitous His-tag peptide enhances its Cu2+ binding affinity.” Dalton Transactions, 2019, 48, 13567–13579. DOI: https://doi.org/10.1039/c9dt01635j

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Łoboda Dorota; Rowińska-Żyrek Magdalena. “Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II).” Dalton Transactions, 2018, 47, 2646–2654. DOI: https://doi.org/10.1039/c7dt04403h

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Łoboda Dorota; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Antimicrobial peptide–metal ion interactions : a potential way of activity enhancement.” New Journal of Chemistry, 2018, 42, 7560–7568. DOI: https://doi.org/10.1039/c7nj04709f

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Hecel Aleksandra; Wątły Joanna; Rowińska-Żyrek Magdalena; Świątek-Kozłowska Jolanta; Kozłowski Henryk. “Histidine tracts in human transcription factors: insight into metal ion coordination ability.” Journal of Biological Inorganic Chemistry, 2018, 23, 81–90. DOI: https://doi.org/10.1007/s00775-017-1512-x

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Wątły Joanna; Hecel Aleksandra; Rowińska-Żyrek Magdalena; Kozłowski Henryk. “Impact of histidine spacing on modified polyhistidine tag : metal ion interactions.” Inorganica Chimica Acta, 2018, 472, 119–126. DOI: https://doi.org/10.1016/j.ica.2017.06.053

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Bellotti Denise; Łoboda Dorota; Rowińska-Żyrek Magdalena; Remelli Maurizio. “Investigation on the metal binding sites of a putative Zn(II) transporter in opportunistic yeast species Candida albicans.” New Journal of Chemistry, 2018, 42, 8123–8130. DOI: https://doi.org/10.1039/c8nj00533h

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Rowińska-Żyrek Magdalena. “Metal interactions with the transmembrane region of HupE Ni2+ transporter explain its efficiency.” Journal of Inorganic Biochemistry, 2018, 180, 33–38. DOI: https://doi.org/10.1016/j.jinorgbio.2017.11.026

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Łodyga-Chruścińska Elżbieta; Pilo Maria; Zucca Antonio; Garribba Eugenio; Klewicka Elżbieta; Rowińska-Żyrek Magdalena; Symonowicz Marzena; Chruściński Longin; Cheshchevik Vitalij T. “Physicochemical, antioxidant, DNA cleaving properties and antimicrobial activity of fisetin-copper chelates.” Journal of Inorganic Biochemistry, 2018, 180, 101–118. DOI: https://doi.org/10.1016/j.jinorgbio.2017.12.006

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Miller Adriana; Dudek Dorota; Potocki Sławomir; Czapor-Irzabek Hanna; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding?” Metallomics, 2018, 10, 1631–1637. DOI: https://doi.org/10.1039/c8mt00275d

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Wątły Joanna; Hecel Aleksandra; Kołkowska Paulina; Kozłowski Henryk; Rowińska-Żyrek Magdalena. “Poly-Xaa sequences in proteins - biological role and interactions with metal ions : chemical and medical aspects.” Current Medicinal Chemistry, 2018, 25, 22–48. DOI: https://doi.org/10.2174/0929867324666170428104928

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Remelli Maurizio; Brasili Davide; Guerrini Remo; Pontecchiani Fabio; Potocki Sławomir; Rowińska-Żyrek Magdalena; Wątły Joanna; Kozłowski Henryk. “Zn(II) and Ni(II) complexes with poly-histidyl peptides derived from a snake venom.” Inorganica Chimica Acta, 2018, 472, 149–156. DOI: https://doi.org/10.1016/j.ica.2017.05.070

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Rowińska-Żyrek Magdalena. “Periplasmic HupE region-Ni2+ interactions: thermodynamics, binding mode and competition with Cu2+ and Zn2+.” Inorganica Chimica Acta, 2017, 460, 141–147. DOI: https://doi.org/10.1016/j.ica.2016.08.007

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Łoboda Dorota; Rowińska-Żyrek Magdalena. “Zinc binding sites in Pra1, a zincophore from Candida albicans.” Dalton Transactions, 2017, 46, 13695–13703. DOI: https://doi.org/10.1039/c7dt01675a

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Łoboda Dorota; Rowińska-Żyrek Magdalena. “Zn(II) - pramlintide : stability, binding sites and unexpected aggregation.” Journal of Inorganic Biochemistry, 2017, 174, 150–155. DOI: https://doi.org/10.1016/j.jinorgbio.2017.06.008

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Rowińska-Żyrek Magdalena. “Coordination of Zn2+ and Cu2+ to the membrane disrupting fragment of amylin.” Dalton Transactions, 2016, 45, 8099–8106. DOI: https://doi.org/10.1039/c6dt00628k

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Walencik Paulina K.; Wątły Joanna; Rowińska-Żyrek Magdalena. “Fungal zinc homeostasis - a tug of war between the pathogen and host.” Current Medicinal Chemistry, 2016, 23, 3717–3729. DOI: https://doi.org/10.2174/0929867323666160817163834

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Kołkowska Paulina; Hecel Aleksandra; Kędzierska Dorota; Ostrowska Małgorzata; Walencik Paulina K.; Wątły Joanna; Zdyb Karolina; Spodzieja Marta; Rodziewicz-Motowidlo Sylwia; Potocki Sławomir; Łuczkowski Marek; Gumienna-Kontecka Elżbieta; Rowińska-Żyrek Magdalena. “HENRYK - an endless source of metal coordination surprises.” Journal of Inorganic Biochemistry, 2016, 163, 258–265. DOI: https://doi.org/10.1016/j.jinorgbio.2016.02.030

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Skilandat Miriam; Rowińska-Żyrek Magdalena; Sigel Roland K. O. “Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme.” RNA - A Publication of the RNA Society, 2016, 22, 750–763. DOI: https://doi.org/10.1261/rna.053843.115

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Wątły Joanna; Potocki Sławomir; Rowińska-Żyrek Magdalena. “Zinc homeostasis at the bacteria/host interface : from coordination chemistry to nutritional immunity.” Chemistry-A European Journal, 2016, 22, 15992–16010. DOI: https://doi.org/10.1002/chem.201602376

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Lodyga-Chruscinska Elzbieta; Symonowicz Marzena; Sykula Anna; Bujacz Anna; Garribba Eugenio; Rowińska-Żyrek Magdalena; Oldziej Stanisław; Klewicka Elżbieta; Janicka Magdalena; Krolewska Karolina; Cieślak Marcin; Brodowska Katarzna; Chruściński Longin. “Chelating ability and biological activity of hesperetin Schiff base.” Journal of Inorganic Biochemistry, 2015, 143, 34–47. DOI: https://doi.org/10.1016/j.jinorgbio.2014.11.005

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Rowińska-Żyrek Magdalena; Salerno Milena; Kozłowski Henryk. “Neurodegenerative diseases – understanding their molecular bases and progress in the development of potential treatments.” Coordination Chemistry Reviews, 2015, 284, 298–312. DOI: https://doi.org/10.1016/j.ccr.2014.03.026

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Rowińska-Żyrek Magdalena; Zakrzewska-Czerwińska J.; Zawilak-Pawlik Anna; Kozłowski Henryk. “Ni2+ chemistry in pathogens - a possible target for eradication.” Dalton Transactions, 2014, 43, 8976–8989. DOI: https://doi.org/10.1039/c4dt00421c

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Skilandat Miriam; Rowińska-Żyrek Magdalena; Sigel Roland K. O. “Solution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domain.” Journal of Biological Inorganic Chemistry, 2014, 19, 903–912. DOI: https://doi.org/10.1007/s00775-014-1125-6

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Pontecchiani Fabio; Simonovsky Eyal; Wieczorek Robert; Barbosa Nuno A.; Rowińska-Żyrek Magdalena; Potocki Sławomir; Remelli Maurizio; Miller Yifat; Kozłowski Henryk. “The unusual binding mechanism of Cu(II) ions to the poly-histidyl domain of a peptide found in the venom of an African viper.” Dalton Transactions, 2014, 43, 16680–16689. DOI: https://doi.org/10.1039/c4dt02257b

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Rowińska-Żyrek Magdalena; Skilandat Miriam; Sigel Roland K. O. “Hexaamminecobalt(III) - probing metal ion binding sites in nucleic acids by NMR spectroscopy.” Zeitschrift für Anorganische und Allgemeine Chemie, 2013, 639, 1313–1320. DOI: https://doi.org/10.1002/zaac.201300123

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Rowińska-Żyrek Magdalena; Witkowska Danuta; Potocki Sławomir; Remelli Maurizio; Kozłowski Henryk. “His-rich sequences- is plagiarism from nature a good idea?” New Journal of Chemistry, 2013, 37, 58–70. DOI: https://doi.org/10.1039/C2NJ40558J

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Kozłowski Henryk; Potocki Sławomir; Remelli Maurizio; Rowińska-Żyrek Magdalena; Valensin Daniela. “Specific metal ion binding sites in unstructured regions of proteins.” Coordination Chemistry Reviews, 2013, 257, 2625–2638. DOI: https://doi.org/10.1016/j.ccr.2013.01.024

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Rowińska-Żyrek Magdalena; Potocki Sławomir; Witkowska Danuta; Valensin Daniela; Kozłowski Henryk. “The zinc-binding fragment of HypA from Helicobacter pylori: a tempting site also for nickel ions.” Dalton Transactions, 2013, 42, 6012–6020. DOI: https://doi.org/10.1039/c2dt32195e

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Chiera Nadine M.; Rowińska-Żyrek Magdalena; Wieczorek Robert; Guerrini Remo; Witkowska Danuta; Remelli Maurizio; Kozłowski Henryk. “Unexpected impact of the number of glutamine residues on metal complex stability.” Metallomics, 2013, 5, 214–221. DOI: https://doi.org/10.1039/c3mt20166j

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Witkowska Danuta; Valensin Daniela; Rowińska-Żyrek Magdalena; Karafova Anna; Kamysz Wojciech; Kozłowski Henryk. “Coordination of Ni2+ and Cu2+ to metal ion binding domains of E.coli SlyD protein.” Journal of Inorganic Biochemistry, 2012, 107, 73–81. DOI: https://doi.org/10.1016/j.jinorgbio.2011.11.012

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Potocki Sławomir; Rowińska-Żyrek Magdalena; Witkowska Danuta; Pyrkosz Monika J.; Szebesczyk Agnieszka; Krzywoszyńska Karolina; Kozłowski Henryk. “Metal transport and homeostasis within the human body : toxicity associated with transport abnormalities.” Current Medicinal Chemistry, 2012, 19, 2738–2759. DOI: https://doi.org/10.2174/092986712800609698

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Witkowska Danuta; Rowińska-Żyrek Magdalena; Valensin Gianni; Kozłowski Henryk. “Specific poly-histidyl and poly-cysteil protein sites involved in Ni2+ homeostasis in Helicobacter pylori. Impact of Bi3+ ions on Ni2+ binding to proteins. Structural and thermodynamic aspects.” Coordination Chemistry Reviews, 2012, 256, 133–148. DOI: https://doi.org/10.1016/j.ccr.2011.06.014

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Witkowska Danuta; Politano R.; Rowińska-Żyrek Magdalena; Guerrini Remo; Remelli Maurizio; Kozłowski Henryk. “The coordination of NiII and CuII ions to the polyhistidyl motif of Hpn protein: is it as strong as we think?” Chemistry-A European Journal, 2012, 18, 11088–11099. DOI: https://doi.org/10.1002/chem.201200780

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Pap József Sándor; Szyrwiel Łukasz; Rowińska-Żyrek Magdalena; Nikitin K.; Fritsky Igor O.; Kozłowski Henryk. “An efficient copper(III) catalyst in the four electron reduction of molecular oxygen by L-ascorbic acid.” Journal of Molecular Catalysis A-Chemical, 2011, 334, 77–82. DOI: https://doi.org/10.1016/j.molcata.2010.10.026

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Potocki Sławomir; Rowińska-Żyrek Magdalena; Valensin Daniela; Krzywoszyńska Karolina; Witkowska Danuta; Łuczkowski Marek; Kozłowski Henryk. “Metal binding ability of cysteine-rich peptide domain of ZIP13 Zn2+ ions transporter.” Inorganic Chemistry, 2011, 50, 6135–6145. DOI: https://doi.org/10.1021/ic200270p

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Krzywoszyńska Karolina; Rowińska-Żyrek Magdalena; Witkowska Danuta; Potocki Sławomir; Łuczkowski Marek; Kozłowski Henryk. “Polythiol binding to biologically relevant metal ions.” Dalton Transactions, 2011, 40, 10434–10439. DOI: https://doi.org/10.1039/c1dt10562k

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Rowińska-Żyrek Magdalena; Witkowska Danuta; Bielińska S.; Kamysz Wojciech; Kozłowski Henryk. “The -Cys-Cys-motif in Helicobacter pylori's Hpn and HspA proteins is an essential anchoring site for metal ions.” Dalton Transactions, 2011, 40, 5604–5610. DOI: https://doi.org/10.1039/c1dt10187k

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Rowińska-Żyrek Magdalena; Witkowska Danuta; Valensin Daniela; Kamysz Wojciech; Kozłowski Henryk. “The C terminus of HspA–a potential target for native Ni(II) and Bi(III) anti-ulcer drugs.” Dalton Transactions, 2010, 39, 5814–5826. DOI: https://doi.org/10.1039/C0DT00013B

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Żyrek Magdalena; Gumienna-Kontecka Elżbieta; Szewczuk Zbigniew; Fritsky Igor O.; Kozłowski Henryk. “Copper(II)-aminohydroxamate ternary complexes evidenced by mass spectrometry.” Arkivoc, 2009, 145–157. DOI: https://doi.org/10.3998/ark.5550190.0010.312

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Valensin Daniela; Szyrwiel Łukasz; Camponeschi Francesca; Rowińska-Żyrek Magdalena; Molteni E.; Jankowska Elżbieta; Szymańska Aneta; Gaggelli Elena; Valensin Gianni; Kozłowski Henryk. “Heteronuclear and homonuclear Cu2+ and Zn2+ complexes with multihistidine peptides based on zebrafish prion-like protein.” Inorganic Chemistry, 2009, 48, 7330–7340. DOI: https://doi.org/10.1021/ic9008202

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Rowińska-Żyrek Magdalena; Valensin Daniela; Szyrwiel Łukasz; Grzonka Z.; Kozłowski Henryk. “Specific interactions of Bi(III) with the Cys-Xaa-Cys unit of a peptide sequence.” Dalton Transactions, 2009, 9131–9140. DOI: https://doi.org/10.1039/b913430a

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Book chapters:

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1. Gumienna-Kontecka E., Rowińska-Żyrek M., Łuczkowski M.,* The role of trace elements in living organisms.

Recent advances in trace elements, Hoboken: John Wiley and Sons , 2018, 177-206, ISBN 9781119133773.

2. Rowińska-Żyrek M.*, Kozłowski H., Nickel binding sites : coordination modes and thermodynamics / The biological chemistry of nickel., Cambridge: Royal Society of Chemistry, 2017, 43-59 , ISBN 978-1-78262-498-1 10.1039/9781788010580-00043.

3. Musiari A., Rowińska-Żyrek M., Gallo S., Sigel R. K. O.*, Metal ions in ribozymes and riboswitches / DNA in supramolecular chemistry and nanotechnology., Chichester: John Wiley and Sons, 2015, 412-433, ISBN 978-1-118-69686-6, 10.1002/9781118696880.ch5

4. Rowińska-Żyrek M., Valensin D., Łuczkowski M., Kozłowski H.*, Prion disease / RSC Metallobiology Series. No. 1, Mechanisms and metal involvement in neurodegenerative diseases., Cambridge: Royal Society of Chemistry, 2013, 118-162, ISBN 978-1-84973-588-9, 10.1039/9781849735896-00118.

5. Kozłowski H., Witkowska D., Rowińska-Żyrek M.*, Chemia nieorganiczna i medycyna / Misja nauk chemicznych., Poznań: Wydawnictwo Nauka i Innowacje, 2011, 141-151, ISBN 978-83-934106-0-6.

 

 

Edited book:

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1. Zamble D., Rowińska-Żyrek M., Kozłowski H., The biological chemistry of nickel., Cambridge: Royal Society of Chemistry, 2017, 1-380, ISBN 978-1-78262-498-1, 10.1039/9781788010580.