Opus 21

Small, well-armed fighters vs. powerful, devastating enemies - modified peptide complexes from human saliva in the fight against pathogenic microbes

GRANT NO

DATES

The aim of this project is the design of AMP-based, metabolically stable, non-toxic, metal-enhanced peptidomimetics to eradicate pathogenic microorganisms from the oral cavity. Incorporation of unnatural occurring building blocks to native peptides (e.g. in the sites most prone to metabolic degradation) can alter their physicochemical properties without impairing the antimicrobial activity, which is crucial in the design of novel, more effective peptidomimetics.

The outcome of this work will be novel, proteolytically stable and potent antimicrobial derivatives of selected salivary peptides and their Zn(II) and Cu(II) complexes.

Published papers in the frame of the project:

OPUS 21

Small, well-armed fighters vs. powerful, devastating enemies - modified peptide complexes from human saliva in the fight against pathogenic microbes

GRANT NO

DATES

Biologically Active Metallopeptides Research Group

University of Wrocław
Department of Chemistry

OPUS 21

Small, well-armed fighters vs. powerful, devastating enemies - modified peptide complexes from human saliva in the fight against pathogenic microbes

GRANT NO

DATES

Biologically Active Metallopeptides Research Group

University of Wrocław Department of Chemistry

University of Wrocław
Department of Chemistry