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The aim of this project is the design of AMP-based, metabolically stable, non-toxic, metal-enhanced peptidomimetics to eradicate pathogenic microorganisms from the oral cavity. Incorporation of unnatural occurring building blocks to native peptides (e.g. in the sites most prone to metabolic degradation) can alter their physicochemical properties without impairing the antimicrobial activity, which is crucial in the design of novel, more effective peptidomimetics.

The outcome of this work will be novel, proteolytically stable and potent antimicrobial derivatives of selected salivary peptides and their Zn(II) and Cu(II) complexes.

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